General Information of This Metabolic Reaction (MR) (ID:
MR000985) |
Formula |
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Reactant |
Etravirine metabolite M3 |
Product |
Etravirine metabolite M4 |
Reactant Info
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Product Info
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Metabolic Enzyme
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Mephenytoin 4-hydroxylase (CYP2C19)
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DME Info
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Metabolic Type
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Oxidation
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Hydroxylation
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Other MR(s) Related to The Reactant of This MR |
Other MR(s) That Produce The Reactant of This MR
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References |
1 |
Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism. Drug Metab Dispos. 2012 Apr;40(4):803-14.
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2 |
Clinical pharmacokinetics and pharmacodynamics of etravirine. Clin Pharmacokinet. 2009;48(9):561-74.
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