Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001006)
Formula Reactant SCH 57871 Product ACP-5461
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001007 Ezetimibe SCH 57871 Conjugation - Glucuronidation Ezetimibe [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000146 Almotriptan malate metabolite M3 ACP-5461 Other reaction - Tautomerisation Almotriptan malate [2]
MR000016 ACP-5531 ACP-5461 Oxidation - N-Dealkylation Acalabrutinib [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000147 ACP-5461 LAS 31911 Other reaction - Dehydration Almotriptan malate [2]
References
1 Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94.
2 Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46.
3 Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans Drug Metab Dispos. 2019 Feb;47(2):145-154. doi: 10.1124/dmd.118.084459.

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