Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001056)
Formula Reactant 5,6-Dihydro-5-fluorouracil Product Fluoro-beta-ureidopropionate
Reactant Info Product Info
Metabolic Enzyme Dihydropyrimidinase (DPYS) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001055 5-fluorouracil 5,6-Dihydro-5-fluorouracil Reduction - Reduction Floxuridine [1], [2]
MR005273 Fluorouracil 5-FUH2 Oxidation - Dehydrogenation Tegafur-uracil [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005274 5-FUH2 FUPA Hydrolysis - Hydrolysis Tegafur-uracil [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001057 Fluoro-beta-ureidopropionate Alpha-Fluoro-beta-alanine Hydrolysis - Hydrolysis Floxuridine [1], [2]
References
1 Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability. Mol Pharm. 2008 Sep-Oct;5(5):717-27.
2 The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, -fluoro--ureidopropionate, -fluoro--alanine using LC-MS J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Apr 15;879(13-14):915-20. doi: 10.1016/j.jchromb.2011.02.045.
3 DrugBank(Pharmacology-Metabolism):Tegafur-uracil

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