Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001060)
Formula Reactant Fluconazole Product Fluconazole N-oxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001059 Fluconazole Fluconazole O-Glucuronidated metabolite Conjugation - Glucuronidation Fluconazole [1], [2]
References
1 The disposition and metabolism of [14C]fluconazole in humans Drug Metab Dispos. 1991 Jul-Aug;19(4):764-7.
2 Investigation into UDP-glucuronosyltransferase (UGT) enzyme kinetics of imidazole- and triazole-containing antifungal drugs in human liver microsomes and recombinant UGT enzymes. Drug Metab Dispos. 2010 Jun;38(6):923-9.

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