Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001082)
Formula
MTR
SVG example
Reactant 5-Methyltetrahydrofolate Product Methionine
Reactant Info Product Info
Metabolic Enzyme Vitamin B12 methionine synthase (MTR) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001081 5,10-methylene tetrahydrofolate (THF) 5-Methyltetrahydrofolate Unclear Folic acid [1]
MR008762 5,10-methylenetetrahydrofolate 5-Methyltetrahydrofolate Unclear - Unclear Leucovorin Calcium [2]
MR008767 5,10-methylenetetrahydrofolate 5-Methyltetrahydrofolate Unclear - Unclear Leucovorin [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008763 5-Methyltetrahydrofolate Tetrahydrofolate Unclear - Unclear Leucovorin Calcium [2]
MR008768 5-Methyltetrahydrofolate Tetrahydrofolate Unclear - Unclear Leucovorin [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000069 Ademetionine Methionine Unclear Ademetionine [3]
MR004273 2-Keto-4-methylthiobutyrate Methionine Unclear Methylthioribose phosphate [4]
MR004268 MTR-1-P Methionine Unclear Methylthioadenosine [5]
MR003670 Betaine Methionine Unclear IP-302 [6]
References
1 DrugBank(Pharmacology-Metabolism)Folic acid
2 Disposition of leucovorin and its metabolites in dietary folic acid-deplete mice - comparison between tumor, liver, and plasma
3 DrugBank(Pharmacology-Metabolism)Ademetionine
4 The metabolism of 5'-methylthioadenosine and 5-methylthioribose 1-phosphate in Saccharomyces cerevisiae
5 Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategies
6 Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline

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