Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001088)
Formula Reactant R406 Product R406 N-glucuronide metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Conjugation - N-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001092 Fostamatinib R406 Unclear Fostamatinib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001087 R406 R529 Unclear Fostamatinib [2]
References
1 Metabolism of fostamatinib, the oral methylene phosphate prodrug of the spleen tyrosine kinase inhibitor R406 in humans: contribution of hepatic and gut bacterial processes to the overall biotransformation Drug Metab Dispos. 2010 Jul;38(7):1166-76. doi: 10.1124/dmd.110.032151.
2 DrugBank(Pharmacology-Metabolism)Fostamatinib

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.