Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001123)
Formula
SVG example
Reactant Gemfibrozil metabolite M1 Product Gemfibrozil metabolite M3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001124 Gemfibrozil Gemfibrozil metabolite M1 Oxidation - 5-Hydroxylation Gemfibrozil [1], [2], [3]
References
1 The metabolism of gemfibrozil Proc R Soc Med. 1976;69 Suppl 2(Suppl 2):11-4.
2 Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides Br J Clin Pharmacol. 2018 Jun;84(6):1279-1289. doi: 10.1111/bcp.13557.
3 Clinical pharmacokinetics of fibric acid derivatives (fibrates). Clin Pharmacokinet. 1998 Feb;34(2):155-62.

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