Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001176)
Formula Reactant Indapamide metabolite M1 Product Indapamide metabolite M3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001182 Indapamide Indapamide metabolite M1 Oxidation - Oxidation Indapamide [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001177 Indapamide metabolite M3 Indapamide metabolite M2 Oxidation - Oxidation Indapamide [1]
References
1 Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions. Drug Metab Dispos. 2009 Mar;37(3):672-84.
2 Vasorelaxant actions of 5-OH-indapamide, a major metabolite of indapamide: comparison with indapamide, hydrochlorothiazide and cicletanine Eur J Pharmacol. 1994 Apr 21;256(2):185-91. doi: 10.1016/0014-2999(94)90244-5.

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