Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001181)
Formula Reactant Indapamide epoxide intermediate Product Indapamide metabolite M6
Reactant Info Product Info
Metabolic Type Oxidation - Dihydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001184 Indapamide Indapamide epoxide intermediate Oxidation - Oxidation Indapamide [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001180 Indapamide epoxide intermediate Indapamide glutathione conjugate M7 Conjugation - Glutathione Conjugation Indapamide [1]
References
1 Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions. Drug Metab Dispos. 2009 Mar;37(3):672-84.

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