Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001194)
Formula
SVG example
Glucuronidation
Reactant Indinavir sulfate Product Indinavir sulfate metabolite M1
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001193 Indinavir sulfate Indinavir sulfate metabolite M3 Oxidation - Hydroxylation Indinavir sulfate [1]
MR001191 Indinavir sulfate Indinavir sulfate metabolite M4a Oxidation - Oxidation Indinavir sulfate [1]
MR001195 Indinavir sulfate Indinavir sulfate metabolite M4b Oxidation - Hydroxylation Indinavir sulfate [1]
MR001192 Indinavir sulfate Indinavir sulfate metabolite M6 Oxidation - N-Depyridomethylation Indinavir sulfate [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001751 Niraparib Niraparib metabolite M1 Hydrolysis - Amide Hydrolysis Niraparib [3], [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001750 Niraparib metabolite M1 Niraparib metabolite M10 Unclear Niraparib [3], [5]
References
1 Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A. Biochem Pharmacol. 1997 Apr 25;53(8):1187-95.
2 Involvement of CYP3A4 and MDR1 in altered metabolism and transport of indinavir in 1,25(OH)(2)D(3)-treated Caco-2 cells. Eur J Pharm Sci. 2023 Apr 1;183:106396. doi: 10.1016/j.ejps.2023.106396.
3 Human mass balance study and metabolite profiling of (14)C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer Invest New Drugs. 2017 Dec;35(6):751-765. doi: 10.1007/s10637-017-0451-2.
4 Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1;1040:14-21. doi: 10.1016/j.jchromb.2016.11.020.
5 P-Glycoprotein (ABCB1/MDR1) Controls Brain Penetration and Intestinal Disposition of the PARP1/2 Inhibitor Niraparib. Mol Pharm. 2021 Dec 6;18(12):4371-4384. doi: 10.1021/acs.molpharmaceut.1c00553.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.