Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR001214)
Formula	N-Demethylation; Oxidation
	Reactant	Irbesartan-TP335		Product	Irbesartan-TP267
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Oxidation - N-Demethylation; Oxidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR001218	Irbesartan	Irbesartan-TP335	Oxidation - Hydrolysis; N-Demethylation	Irbesartan	[1], [2]

References
1	Biotransformation of irbesartan in man Drug Metab Dispos. 1998 May;26(5):408-17.
2	Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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