Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001232)
Formula
SVG example
Reactant Acetylisoniazid Product Acethydrazide
Reactant Info Product Info
Metabolic Enzyme N-acetyltransferase 2 (NAT2) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001239 Isoniazid Acetylisoniazid Conjugation - Acetylation Isoniazid [1], [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001233 Acetylisoniazid Isonicotinic acid Unclear Isoniazid [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001237 Hydrazine Acethydrazide Conjugation - Acetylation Isoniazid [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001234 Acethydrazide Diacetylhydrazine Conjugation - Acetylation Isoniazid [1]
MR001235 Acethydrazide Hydrazine Oxidation - Deacetylation Isoniazid [1]
MR001236 Acethydrazide Isoniazid reactive metabolite Unclear Isoniazid [1]
References
1 Exploration of inhibition potential of isoniazid and its metabolites towards CYP2E1 in human liver microsomes through LC-MS/MS analysis J Pharm Biomed Anal. 2021 Sep 5;203:114223. doi: 10.1016/j.jpba.2021.114223.
2 Molecular mechanism for the activation of the potent hepatotoxin acetylhydrazine: Identification of the initial N-centered radical and the secondary C-centered radical intermediates. Free Radic Biol Med. 2023 Aug 1;204:20-27. doi: 10.1016/j.freeradbiomed.2023.04.010.
3 Quantitative Analysis of Isoniazid and Its Four Primary Metabolites in Plasma of Tuberculosis Patients Using LC-MS/MS. Molecules. 2022 Dec 6;27(23):8607. doi: 10.3390/molecules27238607.
4 Isoniazid level and flu-like symptoms during rifapentine-based tuberculosis preventive therapy: A population pharmacokinetic analysis. Br J Clin Pharmacol. 2023 Feb;89(2):714-726. doi: 10.1111/bcp.15527.

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