Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001246)
Formula
SVG example
Denitration
Reactant Isosorbide dinitrate Product Isosorbide 2-nitrate
Reactant Info Product Info
Metabolic Type Other reaction - Denitration
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001245 Isosorbide dinitrate Isosorbide 5-mononitrate Other reaction - Denitration Isosorbide dinitrate [1], [2]
MR001247 Isosorbide dinitrate Isosorbide dinitrate Nitric Oxide Unclear Isosorbide dinitrate [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001244 Isosorbide 2-nitrate Isosorbide Other reaction - Denitration Isosorbide dinitrate [1], [2]
References
1 Isosorbide dinitrate bioavailability, kinetics, and metabolism Clin Pharmacol Ther. 1985 Aug;38(2):140-9. doi: 10.1038/clpt.1985.150.
2 Pharmacokinetics and metabolism of isosorbide-dinitrate after intravenous and oral administration Eur J Clin Pharmacol. 1985;27(6):637-44. doi: 10.1007/BF00547041.
3 Pharmacokinetics of isosorbide mononitrate Am J Cardiol. 1992 Nov 27;70(17):61G-66G. doi: 10.1016/0002-9149(92)90028-w.

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