Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001261)
Formula
SVG example
Reactant Isotretinoin Product All-trans-retinoic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001262 Isotretinoin 4-hydroxy-13-cis-retinoic acid Oxidation - 4-Hydroxylation Isotretinoin [1]
MR001263 Isotretinoin Isotretinoin glucuronide Conjugation - Glucuronidation Isotretinoin [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002987 Alitretinoin all-trans-retinoic acid Unclear - Unclear Alitretinoin [3]
MR005731 Retinal Retinoic acid Unclear Beta carotene [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001252 All-trans-retinoic acid 16-hydroxyisotretinoin Oxidation - 16-Hydroxylation Isotretinoin [2]
MR001253 All-trans-retinoic acid 18-hydroxyisotretinoin Oxidation - 18-Hydroxylation Isotretinoin [2]
MR001254 All-trans-retinoic acid 4-hydroxyretinoic acid Oxidation - 4-Hydroxylation Isotretinoin [5]
MR005734 Retinoic acid 13-cis-retinoic acid Unclear Beta carotene [4]
MR005732 Retinoic acid 4-Oxoretinoic acid Unclear Beta carotene [4]
References
1 The use of isotretinoin in acne Dermatoendocrinol. 2009 May;1(3):162-9. doi: 10.4161/derm.1.3.9364.
2 Human biliary metabolites of isotretinoin: identification, quantification, synthesis, and biological activity Xenobiotica. 1990 Feb;20(2):193-207. doi: 10.3109/00498259009047155.
3 The single-dose pharmacokinetics of alitretinoin and its metabolites are not significantly altered in patients with cirrhosis Br J Dermatol. 2014 Feb;170(2):408-14. doi: 10.1111/bjd.12546.
4 #NAME?
5 DrugBank(Pharmacology-Metabolism)Isotretinoin

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