Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001270)
Formula Reactant 4'-O-monodesmethyl istradefylline Product Istradefylline M1 glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - O-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001273 Istradefylline 4'-O-monodesmethyl istradefylline Oxidation - O-Demethylation Istradefylline [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001271 4'-O-monodesmethyl istradefylline Istradefylline M1 sulfate conjugate Conjugation - Sulfation Istradefylline [1]
References
1 Effects of rifampin on the pharmacokinetics of a single dose of istradefylline in healthy subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201.
2 The effect of CYP3A4 genetic polymorphism and drug interaction on the metabolism of istradefylline Chem Biol Interact. 2022 Oct 1;366:110123. doi: 10.1016/j.cbi.2022.110123.

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