Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001274)
Formula Reactant Istradefylline Product 3',4'-O-didemethyl Istradefylline
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001275 Istradefylline 1-beta-hydroxy-4'-O-demethyl Istradefylline Unclear Istradefylline [1]
MR001276 Istradefylline 1-beta-hydroxylated Istradefylline Oxidation - Hydroxylation Istradefylline [1]
MR001273 Istradefylline 4'-O-monodesmethyl istradefylline Oxidation - O-Demethylation Istradefylline [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001272 3',4'-O-didemethyl Istradefylline Istradefylline metabolite M10 Unclear Istradefylline [1]
References
1 Effects of rifampin on the pharmacokinetics of a single dose of istradefylline in healthy subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201.
2 The effect of CYP3A4 genetic polymorphism and drug interaction on the metabolism of istradefylline Chem Biol Interact. 2022 Oct 1;366:110123. doi: 10.1016/j.cbi.2022.110123.

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