Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001295)
Formula
SVG example
Hydroxylation
Reactant Ixabepilone Product 11-hydroxy ixabepilone
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001292 Ixabepilone Deg-1 Unclear Ixabepilone [1], [2]
MR001293 Ixabepilone Deg-2 Unclear Ixabepilone [1]
MR001294 Ixabepilone Deg-3 Unclear Ixabepilone [1]
References
1 Biotransformation profiling of [(14)C]ixabepilone in human plasma, urine and feces samples using accelerator mass spectrometry (AMS) Drug Metab Pharmacokinet. 2009;24(6):511-22. doi: 10.2133/dmpk.24.511.
2 The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: a first in class epothilone B analogue in late-phase clinical development. Clin Cancer Res. 2008 May 1;14(9):2701-9.

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