Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001315)
Formula
SVG example
Glucuronidation
Reactant 6-hydroxynorketamine Product 6-hydroxynorketamine glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001318 6-hydroxyketamine 6-hydroxynorketamine Oxidation - N-Demethylation Ketamine [1], [2]
MR001311 Norketamine 6-hydroxynorketamine Oxidation - Hydoxylation Ketamine [1], [3], [4]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Metabolism and metabolomics of ketamine: a toxicological approach. Forensic Sci Res. 2017 Feb 20;2(1):2-10.
3 Simultaneous quantitation of ketamine, norketamine and dehydronorketamine in human milk using a novel ultra high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) assay. J Pharm Biomed Anal. 2023 Jun 1;234:115502. doi: 10.1016/j.jpba.2023.115502.
4 The clinical toxicology of ketamine. Clin Toxicol (Phila). 2023 Jun;61(6):415-428. doi: 10.1080/15563650.2023.2212125.

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