Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001320)
Formula
SVG example
N-Demethylation
Reactant 4-hydroxyketamine Product 4-hydroxynorketamine
Reactant Info Product Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001324 Ketamine 4-hydroxyketamine Oxidation - Hydoxylation Ketamine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001313 Norketamine 4-hydroxynorketamine Oxidation - Hydoxylation Ketamine [1], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001317 4-hydroxynorketamine 4-hydroxynorketamine glucuronide Conjugation - Glucuronidation Ketamine [1], [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Metabolism and metabolomics of ketamine: a toxicological approach. Forensic Sci Res. 2017 Feb 20;2(1):2-10.
3 The clinical toxicology of ketamine. Clin Toxicol (Phila). 2023 Jun;61(6):415-428. doi: 10.1080/15563650.2023.2212125.

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