Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001338)
Formula
SVG example
N-Oxidation
Reactant Ketobemidone Product Ketobemidone N-oxide metabolite
Reactant Info Product Info
Metabolic Enzyme Prostaglandin G/H synthase 1 (COX-1) DME Info
Metabolic Type Oxidation - N-Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001335 Ketobemidone Dihydroxy ketobemidone Unclear Ketobemidone [1]
MR001336 Ketobemidone Norketobemidone Oxidation - N-Demethylation Ketobemidone [1], [2]
MR001337 Ketobemidone Reduced ketobemidone Reduction - Reduction Ketobemidone [3]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein. Xenobiotica. 2005 Aug;35(8):785-96.
3 DrugBank(Pharmacology-Metabolism)Ketobemidone hydrochloride

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