Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001376)
Formula
UGT1A3 ...
SVG example
N-Glucuronidation
Reactant Ketotifen Product Ketotifen-N-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
UDP-glucuronosyltransferase 2B10 (UGT2B10) DME Info
Metabolic Type Conjugation - N-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001377 Ketotifen 10alpha-hydroxyl Ketotifen Reduction - Reduction Ketotifen [1]
MR001378 Ketotifen Nor-ketotifen Oxidation - N-Demethylation Ketotifen [2], [1]
References
1 Quantification of ketotifen and its metabolites in human plasma by gas chromatography mass spectrometry Biomed Mass Spectrom. 1983 Mar;10(3):136-42. doi: 10.1002/bms.1200100307.
2 Ketotifen is a Prodrug. Norketotifen is the active metabolite Drug Dev Res. 2022 Apr;83(2):362-367. doi: 10.1002/ddr.21865.

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