Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001389)
Formula
SVG example
3-Hydroxylation
Reactant Labetalol Product Labetalol 3-hydroxylated metabolite (VI)
Reactant Info Product Info
Metabolic Type Oxidation - 3-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001385 Labetalol Labetalol Benzyl glucuronide metabolite (II) Conjugation - O-Glucuronidation Labetalol [1], [2]
MR001388 Labetalol Labetalol Hydroxylated metabolite (IV) Oxidation - 4-Hydroxylation Labetalol [3]
MR001387 Labetalol Labetalol N-glucuronide metabolite Conjugation - O-Glucuronidation Labetalol [1], [2]
MR001386 Labetalol Labetalol Phenolic glucuronide metabolite (III) Conjugation - O-Glucuronidation Labetalol [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001381 Labetalol 3-hydroxylated metabolite (VI) Labetalol C1' Glucuronidated metabolite (VII) Conjugation - O-Glucuronidation Labetalol [4]
MR001382 Labetalol 3-hydroxylated metabolite (VI) Labetalol C3 Glucuronidated metabolite (VIII) Conjugation - O-Glucuronidation Labetalol [4]
MR001380 Labetalol 3-hydroxylated metabolite (VI) Labetalol Theoretical metabolite (IX) Unclear Labetalol [4]
References
1 Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination. Xenobiotica. 2008 Jan;38(1):62-75.
2 Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes Front Pharmacol. 2021 Apr 15;12:655320. doi: 10.3389/fphar.2021.655320.
3 Urinary metabolites of (R),(R)-labetalol Drug Metab Dispos. 1994 Nov-Dec;22(6):866-72.
4 DrugBank(Pharmacology-Metabolism)Labetalol

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