Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001410)
Formula
UGT1A3 ...
SVG example
Glucuronidation
Reactant Lamotrigine Product Lamotrigine-2-N-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001412 Lamotrigine Lamivudine-2-N-methyl metabolite Unclear Lamotrigine [1], [2], [3]
MR001411 Lamotrigine Lamotrigine-5-N-glucuronide Conjugation - Glucuronidation Lamotrigine [1], [4], [3]
References
1 Pharmacokinetics, toxicology and safety of lamotrigine in epilepsy Expert Opin Drug Metab Toxicol. 2006 Dec;2(6):1009-18. doi: 10.1517/17425255.2.6.1009.
2 Simultaneous determination of plasma lamotrigine, lamotrigine N2-glucuronide and lamotrigine N2-oxide by UHPLC-MS/MS in epileptic patients. J Pharm Biomed Anal. 2022 Oct 25;220:115017. doi: 10.1016/j.jpba.2022.115017.
3 UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers. Xenobiotica. 2021 Oct;51(10):1146-1154. doi: 10.1080/00498254.2021.1972492.
4 Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica. 2009 Nov;39(11):826-35.

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