Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001420)
Formula Reactant Reactive Quinoneimine metabolite Product Quinoneimine-GSH conjugate
Reactant Info Product Info
Metabolic Enzyme Glutamate-cysteine ligase catalytic (GCLC) DME Info
Metabolic Type Conjugation - Conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001418 O-dealkylated lapatinib Reactive Quinoneimine metabolite Unclear Lapatinib ditosylate [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001419 Reactive Quinoneimine metabolite Glutathione adducts Unclear Lapatinib ditosylate [1]
References
1 Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib Drug Metab Dispos. 2011 Jun;39(6):1022-30. doi: 10.1124/dmd.110.037531.

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