Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001430)
Formula Reactant Lapatinib ditosylate Product GW42393
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001431 Lapatinib ditosylate GW690006 Unclear Lapatinib ditosylate [1]
MR001428 Lapatinib ditosylate N-dealkylated lapatinib Oxidation - N-Dealkylation Lapatinib ditosylate [1]
MR001429 Lapatinib ditosylate N-hydroxy lapatinib Oxidation - N-Hydroxylation Lapatinib ditosylate [1]
MR001427 Lapatinib ditosylate O-dealkylated lapatinib Oxidation - O-Dealkylation Lapatinib ditosylate [1]
References
1 Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib Drug Metab Dispos. 2011 Jun;39(6):1022-30. doi: 10.1124/dmd.110.037531.

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