Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001434)
Formula	Oxidation
	Reactant	Lenvatinib mesylate metabolite M2	Product	Lenvatinib mesylate metabolite M2'
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Oxidation - Oxidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR010933	Lenvatinib	O-demethyl Lenvatinib	Unclear - Unclear	Lenvatinib	[1]
MR001437	Lenvatinib mesylate	Lenvatinib mesylate metabolite M2	Oxidation - Dealkylation	Lenvatinib mesylate	[2]

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR001435	Lenvatinib mesylate metabolite M2	Lenvatinib mesylate metabolite H	Conjugation - Glucuronidation	Lenvatinib mesylate	[2]

References
1	The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib
2	Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison Invest New Drugs. 2016 Jun;34(3):300-18. doi: 10.1007/s10637-016-0342-y.

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