Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001485)
Formula
SVG example
O-Methylation
Reactant Dopamine Product 3-Methoxytyramine
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Metabolic Type Conjugation - O-Methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001498 Levodopa Dopamine Oxidation - Decarboxylation Levodopa [1]
MR008912 DEC-TA-870 Dopamine Unclear - Unclear Docarpamine [2]
MR009124 Levodopa Dopamine Unclear - Unclear ABBV-951 [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001486 Dopamine 3,4-Dihydroxyphenylacetaldehyde (DOPAL) Oxidation - Oxidative Deamination Levodopa [4]
MR001488 Dopamine Dopamine-3-O-glucuronide Oxidation - N-Dealkylation Levodopa [4]
MR001490 Dopamine Dopamine-3-O-sulfate Conjugation - Sulfation Levodopa [4]
MR001489 Dopamine Dopamine-4-O-glucuronide Oxidation - N-Dealkylation Levodopa [4]
MR001491 Dopamine Dopamine-4-O-sulfate Conjugation - Sulfation Levodopa [4]
MR001487 Dopamine Norepinephrine Oxidation - Hydroxylation Levodopa [4]
MR008915 Dopamine 3,4-dihydroxyphenylacetic acid Unclear - Unclear Docarpamine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006629 Dopamine hydrochloride 3-MT Unclear Dopamine hydrochloride [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006630 3-MT MHPA Unclear Dopamine hydrochloride [5]
MR001492 3-Methoxytyramine 3-methoxy-4-hydroxyacetaldehyde Oxidation - Oxidative Deamination Levodopa [4]
MR008914 3-methoxytyramine Homovanillic acid Unclear - Unclear Docarpamine [2]
References
1 Complexity of dopamine metabolism. Cell Commun Signal. 2013 May 17;11(1):34.
2 Metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine (TA-870) and dopamine after oral administration to rats and dogs
3 Scalable Asymmetric Syntheses of Foslevodopa and Foscarbidopa Drug Substances for the Treatment of Parkinson's Disease
4 DrugBank(Pharmacology-Metabolism)Levodopa
5 Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain

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