Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001500)
Formula
SVG example
Methylation
Reactant Levodopa Product 3-O-Methyldopa
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Metabolic Type Conjugation - Methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001498 Levodopa Dopamine Oxidation - Decarboxylation Levodopa [1]
MR001499 Levodopa Levodopa Methylated metabolite Conjugation - Methylation Levodopa [2]
MR009124 Levodopa Dopamine Unclear - Unclear ABBV-951 [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008693 Methyldopate Hydrochloride 3-O-methyl-alpha-methyldopa Conjugation - O-methylation Methyldopate Hydrochloride [4], [5], [6]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008694 3-O-methyl-alpha-methyldopa 3-O-methyl-alpha-methyldopa sulfate Conjugation - Sulfation Methyldopate Hydrochloride [7]
References
1 Complexity of dopamine metabolism. Cell Commun Signal. 2013 May 17;11(1):34.
2 DrugBank(Pharmacology-Metabolism)Levodopa
3 Scalable Asymmetric Syntheses of Foslevodopa and Foscarbidopa Drug Substances for the Treatment of Parkinson's Disease
4 Sulfate and methyldopa metabolism: metabolite patterns and platelet phenol sulfotransferase activity. Clin Pharmacol Ther. 1985 Mar;37(3):308-15.
5 The metabolism of 14 C-labelled -methyldopa in normal and hypertensive human subjects
6 THE METABOLISM OF METHYLDOPA IN HYPERTENSIVE HUMAN SUBJECTS
7 DrugBank(Pharmacology-Metabolism):Methyldopate Hydrochloride

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