Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001553)
Formula
SVG example
Reactant Lidocaine Product NL-Ethyl-2-methyl-Nj-(2,6-dimethylphenyl)-4-imidazolidin
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001555 Lidocaine . Unclear Lidocaine [1]
MR001551 Lidocaine 2,6-xylidine Unclear Lidocaine [2], [3], [4]
MR001552 Lidocaine 3-hydroxylidocaine Oxidation - Hydroxylation Lidocaine [5]
MR001550 Lidocaine Monoethylglycinexylidide Oxidation - N-De-Ethylation Lidocaine [1], [5]
MR001554 Lidocaine N-hydroxy-lidocaine Oxidation - Hydroxylation Lidocaine [5]
References
1 Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65.
2 Quantification of lidocaine and several metabolites utilizing chemical-ionization mass spectrometry and stable isotope labeling J Pharm Sci. 1977 Aug;66(8):1180-90. doi: 10.1002/jps.2600660834.
3 An innovative nanoparticle-modified carbon paste sensor for ultrasensitive detection of lignocaine and its extremely carcinogenic metabolite residues in bovine food samples: Application of NEMI, ESA, AGREE, ComplexGAPI, and RGB12 algorithms. Food Chem. 2023 Jun 12;426:136579. doi: 10.1016/j.foodchem.2023.136579.
4 In vitro metabolism of lidocaine in subcellular post-mitochondrial fractions and precision cut slices from cattle liver. Toxicol In Vitro. 2021 Oct;76:105228. doi: 10.1016/j.tiv.2021.105228.
5 The Use and Method of Action of Intravenous Lidocaine and Its Metabolite in Headache Disorders Headache. 2018 May;58(5):783-789. doi: 10.1111/head.13298.

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