Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001644)
Formula
SVG example
O-Methylation
Reactant 16alpha-hydroxyethinylestradiol Product 16alpha-methoxyethinylestradiol
Reactant Info Product Info
Metabolic Enzyme Monoamine oxidase type A (MAO-A) DME Info
Metabolic Type Conjugation - O-Methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002725 Ethinyl estradiol 16alpha-hydroxyethinylestradiol Oxidation - 16-Hydroxylation Ethinyl estradiol [1]
MR001649 17alpha-Ethinylestradiol 16alpha-hydroxyethinylestradiol Oxidation - 16-Hydroxylation Mestranol [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007154 Unclear 16alpha-methoxyethinylestradiol Conjugation - O-methylation Ethinylestradiol propanesulfonate [2], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007155 16alpha-methoxyethinylestradiol 16alpha-methoxyethinylestradiol-glucuronide Conjugation - O-glucuronidation Ethinylestradiol propanesulfonate [2], [3]
MR007156 16alpha-methoxyethinylestradiol 16alpha-methoxyethinylestradiol-sulfate Conjugation - Sulfation Ethinylestradiol propanesulfonate [2], [3]
References
1 Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol Drug Metab Dispos. 2004 Nov;32(11):1299-303. doi: 10.1124/dmd.32.11..
2 Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk Eur J Intern Med. 2017 Jul;42:54-60. doi: 10.1016/j.ejim.2017.05.019.
3 Metabolism of 17 alpha-ethinylestradiol by human liver microsomes in vitro: aromatic hydroxylation and irreversible protein binding of metabolites J Clin Endocrinol Metab. 1974 Dec;39(6):1072-80. doi: 10.1210/jcem-39-6-1072.

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