Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001654)
Formula
SVG example
C-Oxidation
Reactant N-Desmethylaminopyrine Product 4-formyl-amino-antipyrine (FAA)
Reactant Info Product Info
Metabolic Type Oxidation - C-Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000170 Aminophenazone N-Desmethylaminopyrine Oxidation - N-Dealkylation Aminophenazone [1]
MR001660 Metamizole sodium N-Desmethylaminopyrine Hydrolysis - Hydrolysis Metamizole sodium [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001655 N-Desmethylaminopyrine 4-amino-antipyrine (AA) Oxidation - N-Demethylation Metamizole sodium [2], [3]
MR001656 N-Desmethylaminopyrine Arachidonoyl-4-methylaminoantipyrinee (ARA-4-MAA) Unclear Metamizole sodium [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001657 4-formyl-amino-antipyrine (FAA) 4-amino-antipyrine (AA) Oxidation - N-Demethylation Metamizole sodium [2], [3]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Metamizole (Dipyrone) and the Liver: A Review of the Literature J Clin Pharmacol. 2019 Nov;59(11):1433-1442. doi: 10.1002/jcph.1512.
3 Clinical pharmacokinetics of dipyrone and its metabolites Clin Pharmacokinet. 1995 Mar;28(3):216-34. doi: 10.2165/00003088-199528030-00004.

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