Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001735)
Formula Reactant Niclosamide Product Niclosamide-2-O-glucuronide metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001734 Niclosamide 3-hydroxy niclosamide Oxidation - Hydroxylation Niclosamide [1]
References
1 Metabolism of the anthelmintic drug niclosamide by cytochrome P450 enzymes and UDP-glucuronosyltransferases: metabolite elucidation and main contributions from CYP1A2 and UGT1A1 Xenobiotica. 2016;46(1):1-13. doi: 10.3109/00498254.2015.1047812.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.