Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001761)
Formula
SVG example
Reactant Nisoldipine Product Nisoldipine metabolite M1
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001760 Nisoldipine Nisoldipine metabolite M13 Oxidation - Dehydrogenation Nisoldipine [1]
MR001759 Nisoldipine Nisoldipine metabolite M9 Unclear Nisoldipine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001737 Nifedipine 2,6-dimethyl-4-(2-nitrophenyl)-5-methoxycarbonyl-pyridine-3-carboxylic acid Unclear Nifedipine [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001736 2,6-dimethyl-4-(2-nitrophenyl)-5-methoxycarbonyl-pyridine-3-carboxylic acid 2-hydroxymethyl-pyridine carboxylic acid Unclear Nifedipine [3]
MR001758 Nisoldipine metabolite M1 Nisoldipine metabolite M2 Oxidation - Dehydrogenation Nisoldipine [1]
References
1 Clinical pharmacokinetics of nisoldipine coat-core Clin Pharmacokinet. 1998 Sep;35(3):191-208. doi: 10.2165/00003088-199835030-00003.
2 Pharmacokinetics and metabolism of nifedipine Hypertension. 1983 Jul-Aug;5(4 Pt 2):II18-24. doi: 10.1161/01.hyp.5.4_pt_2.ii18.
3 CYP3A5 genotype did not impact on nifedipine disposition in healthy volunteers Pharmacogenomics J. 2004;4(1):34-9. doi: 10.1038/sj.tpj.6500218.

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