Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001777)
Formula
SVG example
Reduction
Reactant 5alpha-dihydronorethisterone Product 3alpha,5alpha-tetrahydronorethisterone
Reactant Info Product Info
Metabolic Enzyme Aldo-keto reductase 1C4 (AKR1C4) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001781 Norethindrone acetate 5alpha-dihydronorethisterone Reduction - Reduction Norethindrone acetate [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001776 5alpha-dihydronorethisterone 3beta,5alpha-tetrahydronorethisterone Reduction - Reduction Norethindrone acetate [1]
References
1 Tibolone and its delta-4, 7alpha-methyl norethisterone metabolite are reversible inhibitors of human aromatase J Steroid Biochem Mol Biol. 2007 May;104(3-5):154-60. doi: 10.1016/j.jsbmb.2007.03.027.
2 Hormonal properties of norethisterone, 7alpha-methyl-norethisterone and their derivatives. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):213-22.

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