Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001795)
Formula Reactant E-10-hydroxydesmethylnortriptyline Product Oxonortriptyline
Reactant Info Product Info
Metabolic Type Conjugation - Glycine Conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001794 Desmethylnortriptyline E-10-hydroxydesmethylnortriptyline Oxidation - N-Demethylation Nortriptyline hydrochloride [1], [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes Clin Pharmacol Ther. 1998 Oct;64(4):384-90. doi: 10.1016/S0009-9236(98)90069-8.

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