Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001828)
Formula
SVG example
Hydroxylation
Reactant Omeprazole sulfone metabolite Product 5'-OH omeprazole sulfide metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 102D1 (cyp102) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000954 Esomeprazole Omeprazole sulfone metabolite Oxidation - S-Oxidation Esomeprazole [1], [2]
MR001829 Omeprazole Omeprazole sulfone metabolite Oxidation - Sulfoxidation Omeprazole [3]
References
1 Cytochrome P450 inactivation by pharmaceuticals and phytochemicals: therapeutic relevance Drug Metab Rev. 2008;40(1):101-47. doi: 10.1080/03602530701836704.
2 Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole Clin Pharmacokinet. 2001;40(6):411-26. doi: 10.2165/00003088-200140060-00003.
3 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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