Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001831)
Formula
SVG example
5'-O-Demethylation
Reactant Omeprazole Product 5'-O-Desmethyl omeprazole
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - 5'-O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001832 Omeprazole 3-hydroxyomeprazole Oxidation - 3-Hydroxylation Omeprazole [1]
MR001830 Omeprazole 5-hydroxyomeprazole Oxidation - 5-Hydroxylation Omeprazole [1]
MR001829 Omeprazole Omeprazole sulfone metabolite Oxidation - Sulfoxidation Omeprazole [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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