Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001833)
Formula
SVG example
N-Demethylation
Reactant 7-OH-ondansetron Product 7-hydroxyl-N-desmethyl-ondansetron
Reactant Info Product Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001836 Ondansetron 7-OH-ondansetron Oxidation - Hydroxylation Ondansetron [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001837 Ondansetron 7-hydroxyl-N-desmethyl-ondansetron Oxidation - N-Demethylation Ondansetron [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001834 7-hydroxyl-N-desmethyl-ondansetron N-desmethyl-ondansetron-7-O-beta-D-glucuronide metabolite Conjugation - Glucuronidation Ondansetron [2]
References
1 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
2 Identification of novel ondansetron metabolites using LC/MS(n) and NMR J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Sep 15;1095:138-141. doi: 10.1016/j.jchromb.2018.07.013.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.