Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001968)
Formula Reactant Peficitinib Product Peficitinib metabolite M13
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001967 Peficitinib Peficitinib metabolite M10 Unclear Peficitinib [1]
MR001963 Peficitinib Peficitinib metabolite M12 Unclear Peficitinib [1]
MR001964 Peficitinib Peficitinib metabolite M3 Unclear Peficitinib [1]
MR001965 Peficitinib Peficitinib metabolite M5 Unclear Peficitinib [1]
MR001961 Peficitinib Peficitinib metabolite M6 Unclear Peficitinib [1]
MR001962 Peficitinib Peficitinib metabolite M7 Unclear Peficitinib [1]
MR001966 Peficitinib Peficitinib metabolite M8 Unclear Peficitinib [1]
MR001960 Peficitinib Peficitinib metabolite M9 Unclear Peficitinib [1]
MR001958 Peficitinib Peficitinib metabolite MH2 Unclear Peficitinib [2]
MR001959 Peficitinib Peficitinib metabolite MH4 Unclear Peficitinib [2]
References
1 Identification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans Xenobiotica. 2015;45(9):757-65. doi: 10.3109/00498254.2015.1019594.
2 Pharmacokinetics and Safety of a Single Oral Dose of Peficitinib (ASP015K) in Japanese Subjects With Normal and Impaired Hepatic Function Clin Pharmacol Drug Dev. 2020 Aug;9(6):699-708. doi: 10.1002/cpdd.751.

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