Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002046)
Formula	Oxidation
	Reactant	Pioglitazone metabolite M-II	Product	Mitoglitazone
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Oxidation - Oxidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR002051	Pioglitazone hydrochloride	Pioglitazone metabolite M-II	Oxidation - Oxidation	Pioglitazone hydrochloride	[1], [2]

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR002045	Pioglitazone metabolite M-II	Pioglitazone metabolite M-XI	Oxidation - Oxidation	Pioglitazone hydrochloride	[1], [2]

References
1	Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors. Basic Clin Pharmacol Toxicol. 2006 Jul;99(1):44-51.
2	Simultaneous quantitation of pioglitazone and its metabolites in human serum by liquid chromatography and solid phase extraction J Pharm Biomed Anal. 1996 Feb;14(4):465-73. doi: 10.1016/0731-7085(95)01665-1.

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