Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002055)
Formula
SVG example
Hydroxylation
Reactant Pioglitazone hydrochloride Product Pioglitazone metabolite M-VII
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002050 Pioglitazone hydrochloride Pioglitazone metabolite M-I Oxidation - O-Dealkylation Pioglitazone hydrochloride [1], [2]
MR002051 Pioglitazone hydrochloride Pioglitazone metabolite M-II Oxidation - Oxidation Pioglitazone hydrochloride [1], [2]
MR002054 Pioglitazone hydrochloride Pioglitazone metabolite M-IV Oxidation - Oxidation Pioglitazone hydrochloride [1], [2]
MR002053 Pioglitazone hydrochloride Pioglitazone metabolite M-V Oxidation - Oxidation Pioglitazone hydrochloride [1], [2]
MR002052 Pioglitazone hydrochloride Pioglitazone metabolite M-VI Oxidation - Oxidation Pioglitazone hydrochloride [1]
References
1 Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors. Basic Clin Pharmacol Toxicol. 2006 Jul;99(1):44-51.
2 Simultaneous quantitation of pioglitazone and its metabolites in human serum by liquid chromatography and solid phase extraction J Pharm Biomed Anal. 1996 Feb;14(4):465-73. doi: 10.1016/0731-7085(95)01665-1.

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