Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002061)
Formula
SVG example
Reactant Carboxybenzothiazine metabolite Product Benzothiazine metabolite
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002066 Piroxicam Carboxybenzothiazine metabolite Unclear Piroxicam [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002064 Piroxicam 5'-hydroxypiroxicam Oxidation - 5'-Hydroxylation Piroxicam [1], [2]
MR008910 Piroxicam 5'-Hydroxypiroxicam Unclear - Unclear Ampiroxicam [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002060 5'-hydroxypiroxicam 5'-hydroxypiroxicam glucuronide Conjugation - Glucuronidation Piroxicam [1], [2]
MR002062 Benzothiazine metabolite N-Methylsaccharin Unclear Piroxicam [1], [2]
References
1 In vivo Piroxicam Metabolites: Possible Source for Synthesis of Central Nervous System (CNS) Acting Depressants Cent Nerv Syst Agents Med Chem. 2017;17(3):172-177. doi: 10.2174/1871524917666161111093759.
2 Metabolism of piroxicam by laboratory animals Drug Metab Dispos. 1981 Mar-Apr;9(2):114-8.
3 Pharmacokinetic drug interactions between ampiroxicam and sulfaphenazole in rats

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