Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002070)
Formula
SVG example
Reactant Pitavastatin glucuronide Product Pitavastatin lactone
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002069 Pitavastatin Pitavastatin glucuronide Conjugation - Glucuronidation Pitavastatin calcium [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008858 Pitavastatin-ester-Glu Pitavastatin lactone Unclear - Unclear Pitavastatin [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008859 Pitavastatin lactone Pitavastatin lactone-ether-Glu Unclear - Unclear Pitavastatin [2]
MR002071 Pitavastatin lactone Pitavastatin Hydrolysis - Hydrolysis Pitavastatin calcium [1]
References
1 Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization. Xenobiotica. 2003 Jan;33(1):27-41.
2 Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: similarities and difference in the metabolism of pitavastatin in monkeys and humans

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