Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002085)
Formula
SVG example
Amide Hydrolysis
Reactant Ponatinib hydrochloride Product AP24600
Reactant Info Product Info
Metabolic Type Hydrolysis - Amide Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002083 Ponatinib hydrochloride AP24567 Oxidation - N-Demethylation Ponatinib hydrochloride [1], [2], [3]
MR002084 Ponatinib hydrochloride AP24592 Hydrolysis - Amide Hydrolysis Ponatinib hydrochloride [2]
MR002086 Ponatinib hydrochloride Ponatinib metabolite M3 Oxidation - Oxidtive Deamination Ponatinib hydrochloride [3]
References
1 Novel pathways of ponatinib disposition catalyzed by CYP1A1 involving generation of potentially toxic metabolites. J Pharmacol Exp Ther. 2017 Oct;363(1):12-19.
2 Absorption, metabolism, and excretion of [(14)C]ponatinib after a single oral dose in humans Cancer Chemother Pharmacol. 2017 Mar;79(3):507-518. doi: 10.1007/s00280-017-3240-x.
3 In vitro metabolites characterization of ponatinib in human liver microsomes using ultra-high performance liquid chromatography combined with Q-Exactive-Orbitrap tandem mass spectrometry Biomed Chromatogr. 2020 Jun;34(6):e4819. doi: 10.1002/bmc.4819.

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