Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002091)
Formula
SVG example
Esterase Hydrolysis
Reactant Prasugrel hydrochloride Product R-95913
Reactant Info Product Info
Metabolic Enzyme Butyrylcholine esterase (BCHE) DME Info
Metabolic Type Hydrolysis - Esterase Hydrolysis
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002088 R-95913 R-138727 Unclear Prasugrel hydrochloride [1], [2], [3], [4]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Determination of the active and inactive metabolites of prasugrel in human plasma by liquid chromatography/tandem mass spectrometry Rapid Commun Mass Spectrom. 2007;21(2):169-79. doi: 10.1002/rcm.2813.
3 Interactions of fentanyl with blood platelets and plasma proteins: platelet sensitivity to prasugrel metabolite is not affected by fentanyl under in vitro conditions. Pharmacol Rep. 2023 Apr;75(2):423-441. doi: 10.1007/s43440-023-00447-7.
4 Pharmacokinetic and Pharmacodynamic Modeling and Simulation Analysis of Prasugrel in Healthy Male Volunteers. Clin Pharmacol Drug Dev. 2023 Jan;12(1):21-29. doi: 10.1002/cpdd.1172.

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