Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002097)
Formula
SVG example
Isomerization
Reactant Pravastatin Product 3alpha-isopravastatin
Reactant Info Product Info
Metabolic Type Other reaction - Isomerization
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002103 Pravastatin 3'(S)-hydroxy-pravastatin Oxidation - Oxidation Pravastatin [1]
MR002102 Pravastatin 3'(S)-hydroxy-pravastatin-tetranor Oxidation - Oxidation Pravastatin [1]
MR002098 Pravastatin 6-epi-pravastatin Other reaction - Isomerization Pravastatin [1]
MR002099 Pravastatin Desacylpravastatin Oxidation - Oxidation Pravastatin [1]
MR002100 Pravastatin Pravastatin glucuronide Conjugation - Glucuronidation Pravastatin [1]
MR002101 Pravastatin Triol pravastatin Oxidation - Hydroxylation Pravastatin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002092 3alpha-isopravastatin 5,6-epoxy-3alpha-isopravastatin Oxidation - Oxidation Pravastatin [2], [3], [1]
MR002093 3alpha-isopravastatin 7-hydroxy-3alpha-isopravastatin Oxidation - Oxidation Pravastatin [2], [3], [1]
References
1 Disposition and metabolism of pravastatin sodium in rats, dogs and monkeys Eur J Drug Metab Pharmacokinet. 1992 Apr-Jun;17(2):103-13. doi: 10.1007/BF03188778.
2 Liquid chromatography-tandem mass spectrometric assay for pravastatin and two isomeric metabolites in mouse plasma and tissue homogenates J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 15;878(28):2751-9. doi: 10.1016/j.jchromb.2010.08.015.
3 Effects of mineral oil administration on the pharmacokinetics, metabolism and pharmacodynamics of atorvastatin and pravastatin in mice and dogs Eur J Pharm Sci. 2021 Jun 1;161:105776. doi: 10.1016/j.ejps.2021.105776.

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