Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002110)
Formula
SVG example
Hydroxylation
Reactant Nordazepam Product 4'-hydroxdesalkylprazepam
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004426 Nordazepam Oxazepam Oxidation - C3-hydroxylation Nordazepam [1], [2]
MR000824 Nordazepam Nordiazepam O-glucuronide Conjugation - O-Glucuronidation Diazepam [3]
MR000825 Nordazepam Oxazepam Unclear Diazepam [3], [4], [5]
MR002111 Nordazepam Oxazepam Oxidation - Hydroxylation Prazepam [6], [7], [8]
MR001327 Nordazepam Oxazepam Oxidation - Hydroxylation Ketazolam [9]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005299 Clorazepic acid p-Hydroxynordiazepam Unclear Clorazepic acid [10]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002105 4'-hydroxdesalkylprazepam 4'-hydroxyoxazepam Oxidation - Hydroxylation Prazepam [7], [8]
References
1 Kinetics of sequential metabolism. I. Formation and metabolism of oxazepam from nordiazepam and temazepam in the perfused murine liver
2 Kinetics of sequential metabolism. II. Formation and metabolism of nordiazepam and oxazepam from diazepam in the perfused murine liver
3 Study on the Pharmacokinetics of Diazepam and Its Metabolites in Blood of Chinese People Eur J Drug Metab Pharmacokinet. 2020 Aug;45(4):477-485. doi: 10.1007/s13318-020-00614-8.
4 Pharmacokinetics of Diazepam and Its Metabolites in Urine of Chinese Participants. Drugs R D. 2022 Mar;22(1):43-50. doi: 10.1007/s40268-021-00375-y.
5 Kinetic disposition of diazepam and its metabolites after intravenous administration of diazepam in the horse: Relevance for doping control. J Vet Pharmacol Ther. 2021 Sep;44(5):733-744. doi: 10.1111/jvp.12991.
6 Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects. Drug Metab Rev. 2017 Nov;49(4):451-463.
7 Prazepam metabolism by man Clin Pharmacol Ther. 1970 Nov-Dec;11(6):890-7. doi: 10.1002/cpt1970116890.
8 Prazepam metabolites in dog urine J Pharm Sci. 1970 Mar;59(3):322-5. doi: 10.1002/jps.2600590309.
9 Urinary diazepam metabolite distribution in a chronic pain population J Anal Toxicol. 2014 Apr;38(3):135-42. doi: 10.1093/jat/bku001.
10 DrugBank(Pharmacology-Metabolism):Clorazepic acid

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