Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002137)
Formula
SVG example
Reactant CPQ Product CPOQ
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002147 Primaquine CPQ Unclear Primaquine [1], [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002138 CPQ CPQ-G Conjugation - Glucuronidation Primaquine [1]
MR002136 CPQ CPQ-lac Unclear Primaquine [1]
References
1 Quantitative analysis of primaquine and its metabolites in human urine using liquid chromatography coupled with tandem mass spectrometry J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Dec 15;1213:123517. doi: 10.1016/j.jchromb.2022.123517.
2 Comparative single dose pharmacokinetics and metabolism of racemic primaquine and its enantiomers in human volunteers. Drug Metab Pharmacokinet. 2022 Aug;45:100463. doi: 10.1016/j.dmpk.2022.100463.
3 Synthesis, Biological Activity and In Silico Pharmacokinetic Prediction of a New 2-Thioxo-Imidazoldidin-4-One of Primaquine. Pharmaceuticals (Basel). 2021 Feb 27;14(3):196. doi: 10.3390/ph14030196.
4 Quantitative determination of primaquine-5,6-ortho-quinone and carboxyprimaquine-5,6-ortho-quinone in human erythrocytes by UHPLC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Jan 15;1163:122510. doi: 10.1016/j.jchromb.2020.122510.

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