Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR002158)
Formula	Hydroxylation
	Reactant	Procainamide hydrochloride		Product	Procainamide 4-hydroxylamine
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Oxidation - Hydroxylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR002157	Procainamide hydrochloride	Desethylprocainamide	Oxidation - Deethylation	Procainamide hydrochloride	[1]
MR002156	Procainamide hydrochloride	N-Acetyl-3-hydroxyprocainamide	Oxidation - N-Hydroxylation	Procainamide hydrochloride	[2], [1]

References
1	Metabolites of procainamide and practolol inhibit complement components C3 and C4 Biochem J. 1988 Apr 15;251(2):323-6. doi: 10.1042/bj2510323.
2	Involvement of CYP2D6 activity in the N-oxidation of procainamide in man. Pharmacogenetics. 1999 Dec;9(6):683-96.

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