Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR002181)
Formula	N-Demethylation
	Reactant	Promethazine		Product	Desmethylpromethazine
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Oxidation - N-Demethylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR002182	Promethazine	Promethazine Hydroxy metabolite	Oxidation - Hydroxylation	Promethazine	[1], [2], [3]
MR002180	Promethazine	Promethazine Sulphoxide	Oxidation - Sulphoxidation	Promethazine	[1], [2], [3]

References
1	An HPLC-ESI-MS method for simultaneous determination of fourteen metabolites of promethazine and caffeine and its application to pharmacokinetic study of the combination therapy against motion sickness J Pharm Biomed Anal. 2012 Mar 25;62:119-28. doi: 10.1016/j.jpba.2011.12.033.
2	A liquid chromatographic method for the simultaneous determination of promethazine and three of its metabolites in plasma using electrochemical and UV detectors J Chromatogr Sci. 2001 Feb;39(2):70-2. doi: 10.1093/chromsci/39.2.70.
3	CYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist promethazine in human liver microsomes. Pharmacogenetics. 1996 Oct;6(5):449-57.

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